Prolyl-glycyl-proline (PGP) Peptide Prevents an Increase in Vascular Permeability in Inflammation
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Prolyl-glycyl-proline (PGP) Peptide Prevents an Increase in Vascular Permeability in Inflammation
This study was aimed at investigating the effect of prolyl-glycyl-proline (PGP) tripeptide on vascular permeability in rats with an inflammation. It was found that the peptide reduces the rat paw edema induced by a subcutaneous administration of histamine to the same extent as the conventional anti-inflammatory agent diclofenac. However, an assessment of the relative expression level of the cox...
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15N shielding tensors were determined for the central peptide groups in GGV, AGG, and APG by single-crystal NMR. We find that the angle between the downfield component (delta11) and the N-H or the N-C(delta) (pro) bonds is in the range of 20-23 degrees and in accord with previous solid-state NMR measurements. However, AGG, unlike APG or GGV, has a distorted peptide plane, and delta11 lies appro...
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ژورنال
عنوان ژورنال: Acta Naturae
سال: 2017
ISSN: 2075-8251
DOI: 10.32607/20758251-2017-9-1-52-55